Nanobiotics against antimicrobial resistance: harnessing the power of nanoscale materials and technologies항균제 내성에 대한 나노바이오틱스: 나노 소재 및 기술의 힘 활용Review Published on 2022-08-122022-09-11 Journal: Journal of Nanobiotechnology [Category] SARS, 유전자 메커니즘, [키워드] Antibiotic resistance Antibiotics anticipated antimicrobial resistance Antimicrobials Bacteria Bacterial Efficacy functional interfere lack mechanism MOST nanomaterials Nanotechnology Nanotechnology. pandemic Pathogens penetration positioned SARS-CoV2 shape situation spasmodic surface chemistry treat verge [DOI] 10.1186/s12951-022-01573-9 PMC 바로가기 [Article Type] Review
A comprehensive genomic study, mutation screening, phylogenetic and statistical analysis of SARS-CoV-2 and its variant omicron among different countries국가별 SARS-CoV-2 및 그 변이체 오미크론에 대한 포괄적인 게놈 연구, 돌연변이 스크리닝, 계통 발생 및 통계 분석Article Published on 2022-08-012022-09-11 Journal: Journal of infection and public health [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition Analysis anticipated approach assist average B.1.1.529 B.1.617.2 bioinformatics Brazil changes in Complete confidence conserved Corona coronavirus country COVID-19 Delta determined by domain domains Drug discovery Effect evaluate Evolution full-length genome Genes genetic diversity Genome genome sequence Genome sequences genomic genomic sequence help heterozygosity highest identify in viral in-silico information isolates Japan MSN Mutation mutation analysis offer omicron Omicron variant Omicron variants ORF1 ORF10 ORF1ab ORF7a Phylogenetic Phylogenetic tree Phylogeny polymorphism Population predict prevalent Protein provide resource SARS-CoV-2 selected sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shape Spike protein standard error statistical analysis strain the Spike the vaccine these viruses TRS unique Vaccine variant variants Variation variations viral genome viral genome sequence viral genome. viruses was determined was used were used Wuhan-Hu-1 [DOI] 10.1016/j.jiph.2022.07.002 PMC 바로가기 [Article Type] Article
Contribution of Two-Dose Vaccination Toward the Reduction of COVID-19 Cases, ICU Hospitalizations and Deaths in Chile Assessed Through Explanatory Generalized Additive Models for Location, Scale, and Shape위치, 규모 및 모양에 대한 설명 일반화 가법 모델을 통해 평가된 칠레의 COVID-19 사례, ICU 입원 및 사망 감소를 위한 2회 접종 백신의 기여Article Published on 2022-07-272022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, [키워드] Additive adverse outcome adverse outcomes booster dose booster doses contribute country COVID-19 death deaths dose epidemiological epidemiological data explain explanatory models Future future work GAMLSS models Generalized highlight Hospitalization ICU ICU hospitalizations Inclusion initial location mass vaccination Model outcome pandemic pandemic progresses per day Policy predictor provide R 2 reduce reducing SARS-COV-2 infection scale second dose shape statistical interaction statistically significant Stress Support vaccination vaccination schedule Vaccination Status vaccination. vaccine doses Vaccines variant were used [DOI] 10.3389/fpubh.2022.815036 PMC 바로가기 [Article Type] Article
Beyond GWAS-Could Genetic Differentiation within the Allograft Rejection Pathway Shape Natural Immunity to COVID-19?GWAS를 넘어 동종이식 거부 경로 내 유전적 분화가 COVID-19에 대한 자연 면역을 형성할 수 있습니까?Article Published on 2022-06-032022-09-11 Journal: International Journal of Molecular Sciences [Category] 변종, [키워드] Allograft allograft rejection Analysis annotation antiviral immunity applied Biomarker Biomarkers chromosome chromosome 6 chromosomes clinical presentation component components COVID-19 COVID-19 infection COVID-19 infections cumulative demonstrated differentiation disease Factor Genetic genetic variants genetics Genome-wide association study genomic GWAS Health help hospitalisation Host identify immune response immune responses immune system immunisation Infection investigated KEGG KEGG pathways Linear model majority mapped metabolic pathway metabolic pathways natural nucleotide outcome pathway Pathways Patient rejection resistance risk Risk assessment self Sequencing severe COVID-19 Severe COVID-19 Infection shape single nucleotide Single nucleotide polymorphism single variant SNP SNPs susceptibility Treatment variant whole genome Whole genome sequencing whole genome sequencing. [DOI] 10.3390/ijms23116272 PMC 바로가기 [Article Type] Article
A New Compartment Model of COVID-19 Transmission: The Broken-Link ModelCOVID-19 전파의 새로운 구획 모델: 끊어진 연결 모델Article Published on 2022-06-032022-09-11 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 변종, [키워드] basic reproduction number caused compartment compartment model confirmed case confirmed cases COVID-19 delta variant early stage Epidemic epidemic model exponential growth growth include magnitude mechanism Model New number of infected occur Omicron variant omicron variant. Probability shape Spread suppression Transmission virus [DOI] 10.3390/ijerph19116864 PMC 바로가기 [Article Type] Article
In silico study of substrate chemistry effect on the tethering of engineered antibodies for SARS-CoV-2 detection: Amorphous silica vs goldSARS-CoV-2 검출을 위한 조작된 항체의 테더링에 대한 기질 화학 효과의 실리코 연구: 비정질 실리카 대 금Article Published on 2022-05-012022-09-11 Journal: Colloids and surfaces. B, Biointerfaces [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] accelerated Affect Amorphous Amorphous silica antibodies antibody Antibody immobilization Arm correlation CR3022 cubic determined by Diagnosis Dynamics Effect electrostatic examined explain gold help IgG1 increase Interaction molecular molecular dynamics Orientation primary sequence Result S309 SARS-CoV-2 SARS-CoV-2 immunosensor. shape silica substrate tethering the antibodies the antibody tilt Two surface Two surfaces van der Waal [DOI] 10.1016/j.colsurfb.2022.112400 PMC 바로가기 [Article Type] Article
Mutations of Omicron Variant at the Interface of the Receptor Domain Motif and Human Angiotensin-Converting Enzyme-2수용체 도메인 모티프와 인간 안지오텐신 전환 효소-2의 인터페이스에서 오미크론 변이체의 돌연변이Article Published on 2022-03-062022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 변종, [키워드] AABP unit ACE2 Amino acid Analysis angiotensin angiotensin-converting enzyme-2 Anxiety atomic benefit binding bonding calculated caused changes in complexity in shape and volume components computational modeling contribute evade explain facilitate Human human Angiotensin-converting enzyme immune defense in-depth analysis indicate Interaction interface mitigate Mutation observation omicron Omicron variant partial charge positive RBM receptor binding motif reveal SARS-CoV-2 shape significant changes in significant increase Spike protein Spread the spike protein Vaccines variant variant of SARS-CoV-2 virial transmission [DOI] 10.3390/ijms23052870 PMC 바로가기 [Article Type] Article
Comprehensive characterization of the antibody responses to SARS-CoV-2 Spike protein finds additional vaccine-induced epitopes beyond those for mild infectionSARS-CoV-2 스파이크 단백질에 대한 항체 반응의 포괄적인 특성화는 경증 감염에 대한 것 이외의 추가 백신 유도 에피토프를 찾습니다.Comparative Study Published on 2022-01-242022-09-10 Journal: eLife [Category] 변종, 치료기술, 치료제, [키워드] Affect affected age Alter Analysis antibodies antibody Antibody binding antibody epitope Antibody Response Antigen Bacteria binding C-terminal domain cause chair changes in complicate Comprehensive computing conserved Control covariate COVID-19 COVID-19 pandemic disease DNA fragment dose education effective epitope Epitopes escape escape mutations experiment exposure to faculty FAM feature finding focus foundation funding fusion peptide genetic code help Howard Hughe Howard Hughes Human Humoral response humoral responses identify immune Immune escape immune system implication individual infect infected individuals Infection Infrastructure interfere Laboratory Lower majority mild infection mRNA vaccination mRNA vaccine mutant Mutation mutations NIH not affect not altered occur offered overlapping pandemic pathway Pathways pattern peptide peptides phage phages population level portion Principal component principal component analysis produced producing PROTECT Protein RBD Region regions Research residue route S1 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 spike protein Scholar selected severe disease Severe infection shape small molecule Small molecules specific antibodies specific protein spike Spike protein spike-specific antibodies Spike-specific antibody Spread stick subsequent Support supported target the antibody the antibody response the RBD the S1 subunit the SARS-CoV-2 the Spike the spike protein thought triggering unique vaccinated individual vaccinated individuals vaccination Vaccine Vaccine development vaccine-induced antibodies vaccine-induced antibody variant Variation virus was performed while wild-type [DOI] 10.7554/eLife.73490 PMC 바로가기 [Article Type] Comparative Study
Construction of SARS-CoV-2 virus-like particles in plant식물에서 SARS-CoV-2 바이러스 유사 입자의 구성Article Published on 2022-01-192022-09-10 Journal: Scientific Reports [Category] 치료법, [키워드] acute respiratory syndrome coronavirus antigens approved caused construction coronavirus coronavirus 2 effort Emergency use immunogenicity IMPROVE membrane mutations non-infectious nucleocapsid pandemic Particle Plant biotechnology Plant sciences plants platform public health emergency purified Research respiratory S antigen S protein SARS-CoV-2 SARS-CoV-2 VLP sedimentation severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shape spikes sucrose sucrose cushion Vaccine Vaccine development Vaccines Viral protein Viral proteins Virus-like particle virus-like particles VLP VLPs [DOI] 10.1038/s41598-022-04883-y PMC 바로가기 [Article Type] Article
How Did Awareness, Emotion, and Motivation Shape Behavior Toward COVID-19 in Tunisians?Public Health Published on 2021-12-312022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] AB-Survey age Analysis analyzed ANOVA Awareness Behavior behavior change CFA chi-square test Cognition conducted confirmatory factor analysis COVID-19 Effect emotion emotional Gender General population groups Health help impacts information less limit lockdown Measures men mental health motivation outbreak pandemic pandemic of COVID-19 Participants preventive measures provide Psychological distress shape significant effect significantly more the disease [DOI] 10.3389/fpubh.2021.771686 PMC 바로가기 [Article Type] Public Health